This policy paper will give an overview of the challenges that lay ahead of North Macedonia in the forthcoming period starting with the adoption of a Negotiating Framework and the holding of the First Intergovernmental Conference for accession of the country to the EU. Furthermore, it will discuss the general EU position on a draft Negotiating Framework and the setting it is adopted in, as well as the domestic conditions it will come across. In the end, this paper draws conclusions and recommendations on how North Macedonia could handle the newly arisen situation.